Biological Activity
Selective antagonist of neuromuscular nicotinic receptors α1β1γδ. Displays selectivity for α/δ sites over α/γ sites in Torpedo.
Licensing Information
Sold under license from University of Utah
Technical Data
| M. Wt | 2093.4 |
| Formula | C83H125N27O27S5 |
| Sequence |
RDXCCYHPTCNMSNPQIC (Modifications: X = Hyp, Cys-18 = C-terminal amide, Disulfide bridge between 4 - 10, 5 - 17) |
| Storage | Store at -20°C |
| CAS Number | 170663-33-9 |
| PubChem ID | 90488801 |
| InChI Key | ZUOKYBVKCMQKIN-MLWUHNSQSA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC3=CNC=N3)NC(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(N)=O)NC2=O)[C@@H](C)CC)C(N)=O)NC1=O)[C@@H](C)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 2 mg/ml in 10% acetonitrile |
Preparing Stock Solutions
The following data is based on the product molecular weight 2093.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.48 mL | 2.39 mL | 4.78 mL |
| 5 mM | 0.1 mL | 0.48 mL | 0.96 mL |
| 10 mM | 0.05 mL | 0.24 mL | 0.48 mL |
| 50 mM | 0.01 mL | 0.05 mL | 0.1 mL |
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References
References are publications that support the products' biological activity.
Martinez et al (1995) α-Conotoxin EI, a new nicotinic acetylcholine receptor antagonist with novel selectivity. Biochemistry 34 14519 PMID: 7578057
Park et al (2001) Solution conformation of α-Conotoxin EI, a neuromuscular toxin specific for the α1/δ subunit interface of Torpedo nicotinic acetylcholine receptor. J.Biol.Chem. 276 49028 PMID: 11641403
Lopez-Vera et al (2007) Novel α-conotoxins from Conus spurius and the α-conotoxin EI share high-affinity potentiation and low-affinity inhibition of nicotinic acetylcholine receptors. FEBS Lett. 274 3972 PMID:
Keywords: alpha-Conotoxin EI, supplier, α1β1δγ, alpha1beta1deltagamma, a1b1dg, selective, nAChR, antagonists, Acetylcholine, Nicotinic, Receptors, Non-Selective, Subtypes, Other, α-conotoxin, alpha-conotoxin, EI, a-ConotoxinEI, conotoxins, venoms, Nicotinic, Receptors, (Other, Subtypes), Tocris Bioscience
