Biological Activity
Selective antagonist of α6-containing nicotinic receptors that discriminates between the closely related α6 and α3 subunits (IC50 values are 0.95 and 74.2 nM for rat α6/α3β2β3 and α3β2 receptors respectively).
Licensing Information
Sold under license from University of Utah
Technical Data
| M. Wt | 1981.3 |
| Formula | C79H125N27O25S4 |
| Sequence |
RDPCCSNPVCTVHNPQIC (Modifications: Cys-18 - C-terminal amide, Disulfide bridge between 4 - 10, 5 - 18) |
| Storage | Store at -20°C |
| CAS Number | 669050-68-4 |
| PubChem ID | 90488800 |
| InChI Key | WINQUAHGULGZED-WAIIABLISA-N |
| Smiles | [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)C(NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC3=CNC=N3)NC(=O)[C@@H](NC(=O)C(NC2=O)[C@@H](C)O)C(C)C)[C@@H](C)CC)C(N)=O)NC1=O)C(C)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 2 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1981.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.5 mL | 2.52 mL | 5.05 mL |
| 5 mM | 0.1 mL | 0.5 mL | 1.01 mL |
| 10 mM | 0.05 mL | 0.25 mL | 0.5 mL |
| 50 mM | 0.01 mL | 0.05 mL | 0.1 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Dowell et al (2003) α-Conotoxin PIA is selective for α6 subunit-containing nicotinic acetylcholine receptors. J.Neurosci. 23 8445 PMID: 13679412
Azam and McIntosh (2005) Effect of novel α-Conotoxins on nicotine-stimulated [3H]Dopamine release from rat striatal synaptosomes. J.Pharmacol.Exp.Ther. 312 231 PMID: 15316087
Chi et al (2005) Solution structure of α-conotoxin PIA, a novel antagonist of α6 subunit containing nicotinic acetylcholine receptors. Biochem.Biophys.Res.Comms. 338 1990 PMID:
Keywords: alpha-Conotoxin PIA, supplier, Selective, antagonists, a6, α6, alpha6, containing, nicotinic, receptors, Acetylcholine, Receptors, Non-Selective, Subtypes, nAChR, α-conotoxin, alpha-conotoxin, PIA, a-ConotoxinPIA, conotoxins, venoms, Nicotinic, Receptors, (Other, Subtypes), Tocris Bioscience
