Biological Activity
Selective antagonist of α3β2 nAChR receptors (IC50 values are 9.56 and 252 nM for α3β2 and α7 receptors respectively).
Licensing Information
Sold under license from University of Utah
Technical Data
| M. Wt | 1622.82 |
| Formula | C65H95N19O22S4 |
| Sequence |
GCCSLPPCAANNPDYC (Modifications: Cys-16 = C-terminal amide, Disulfide bridge between 2 - 8, 3 - 16) |
| Storage | Desiccate at -20°C |
| CAS Number | 705300-84-1 |
| PubChem ID | 73755066 |
| InChI Key | VUVGEYBNLLGGBG-MVPSLEAZSA-N |
| Smiles | [H]NCC(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CCCN3C(=O)[C@@H]3CCCN3C(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC2=O)C(N)=O)NC1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 5 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1622.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.62 mL | 3.08 mL | 6.16 mL |
| 5 mM | 0.12 mL | 0.62 mL | 1.23 mL |
| 10 mM | 0.06 mL | 0.31 mL | 0.62 mL |
| 50 mM | 0.01 mL | 0.06 mL | 0.12 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Fainzilber et al (1994) New mollusc-specific α-conotoxins block Aplysia neuronal acetylcholine receptors. Biochemistry 33 9523 PMID: 8068627
Luo et al (1999) Single-residue alteration in α-conotoxin PnIA switches its nAChR subtype selectivity. Biochemistry 38 14542 PMID: 10545176
Everhart et al (2003) Identification of residues that confer α-conotoxin-PnIA sensitivity on the α3 subunit of neuronal nicotinic acetylcholine receptors. J.Pharmacol.Exp.Ther. 306 664 PMID: 12734390
Keywords: alpha-Conotoxin PnIA, supplier, Selective, α3β2, alpha3beta2, a3b2, nAChR, antagonists, Acetylcholine, Nicotinic, Receptors, Non-Selective, Subtypes, Other, α-conotoxin, alpha-conotoxin, PnIA, conotoxins, venoms, Nicotinic, Receptors, (Other, Subtypes), Tocris Bioscience
