Biological Activity
Highly selective, reversible sodium channel blocker; citrate salt of tetrodotoxin.
Technical Data
| M. Wt | 319.27 |
| Formula | C11H17N3O8 |
| Storage | Desiccate at -20°C |
| CAS Number | 18660-81-6 |
| PubChem ID | 16759596 |
| InChI Key | CFMYXEVWODSLAX-CKYAAQHSSA-N |
| Smiles | OC1(CO)[C@H](O4)C(O)[C@@]2([C@@H]([C@@H](O)N3)C1O[C@](O)4[C@H]2O)NC3=N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 31.93 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 319.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.13 mL | 15.66 mL | 31.32 mL |
| 5 mM | 0.63 mL | 3.13 mL | 6.26 mL |
| 10 mM | 0.31 mL | 1.57 mL | 3.13 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.63 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Gleitz et al (1996) The protective action of tetrodotoxin and (±)-kavain on anaerobic glycolysis, ATP content and intracellular Na+ and Ca2+ of anoxic brain vesicles. Neuropharmacology 35 1743 PMID: 9076753
Kao (1972) Pharmacology of tetrodotoxin and saxitoxin. Fed.Proc. 31 1117 PMID: 5032475
Kao (1986) Structure-activity relations of tetrodotoxin, saxitoxin, and analogues. Ann.N.Y.Acad.Sci. 479 52 PMID: 2434008
Merck Index 12 9382 PMID:
Keywords: Tetrodotoxin citrate, supplier, Citrate, salt, Sodium, NaV, Channels, voltage-gated, voltage-dependent, Na+, TTx, citrate, Voltage-gated, Sodium, Channels, Tocris Bioscience
