Biological Activity
Potent casesin kinase 1δ/ε inhibitor (IC50 values are 3.9 and 17 nM, respectively). Mediates circadian rhythm phase-delaying effects in vivo. Attenuates opioid drug seeking behaviour in addiction in vivo models.
Licensing Information
Sold for research purposes under agreement from Pfizer Inc.
Technical Data
| M. Wt | 419.46 |
| Formula | C22H22FN7O |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1293395-67-1 |
| PubChem ID | 51353555 |
| InChI Key | XPWHRQHBPRSUAW-UHFFFAOYSA-N |
| Smiles | NC1=NC(C2=C(C3=CC=C(F)C=C3)N=CN2C4CCN(CC5=NOC=C5)CC4)=CC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.95 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 419.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.38 mL | 11.92 mL | 23.84 mL |
| 5 mM | 0.48 mL | 2.38 mL | 4.77 mL |
| 10 mM | 0.24 mL | 1.19 mL | 2.38 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Wager et al (2014) Casein kinase 1δ/ε inhibitor PF-5006739 attenuates opioid drug-seeking behavior. ACS Chem.Neurosci. 5 1253 PMID: 25299732
Keywords: PF 5006739, supplier, PF5006739, Casesin, kinase, 1δ/ε, delta, epsilon, inhibitors, inhibits, circadian, rhythm, opioid, drug, seeking, behaviour, addiction, Casein, Kinase, 1, Tocris Bioscience
