Biological Activity
Potent 17β-hydroxysteroid dehydrogenase type 5 inhibitor (IC50 = 11 - 49 nM). Suppresses androstenedione-dependent protein-specific antigen (PSA) production and cell proliferation in LNCaP cells in vitro. Orally bioavailable.
Technical Data
| M. Wt | 330.42 |
| Formula | C19H26N2O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1126084-37-4 |
| PubChem ID | 25210792 |
| InChI Key | OXSCPDKUZWPWFR-UHFFFAOYSA-N |
| Smiles | O=C(N1CCC(CC1)CC(C)(O)C)C2=CC3=CC(OC)=CC=C3N2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.04 | 100 | |
| ethanol | 33.04 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 330.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.03 mL | 15.13 mL | 30.26 mL |
| 5 mM | 0.61 mL | 3.03 mL | 6.05 mL |
| 10 mM | 0.3 mL | 1.51 mL | 3.03 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.61 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Kikuchi et al (2014) In vitro and in vivo characterisation of ASP9521: a novel, selective, orally bioavailable inhibitor of 17β-hydroxysteroid dehydrogenase type 5 (17βHSD5; AKR1C3). Invest.New Drugs 32 860 PMID: 24981575
Keywords: ASP 9521, supplier, ASP9521, 17beta, 17B, hydroxysteroid, dehydrogenase, type, 5, inhibitors, inhibits, 17β-HSD5, AK1RC3, potent, orally, bioavailable, Other, Dehydrogenases, Tocris Bioscience
