BiologicalActivity
Potenthepatoselectiveglucokinaseactivator(EC50=90nM).Exhibits>50-foldlivertopancreasratiooftissuedistribution.Reducesfastingandpostprandialglucoselevelswithnohypoglycemiainaratdiabetesmodel.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
TechnicalData
| M.Wt | 396.36 |
| Formula | C18H19F3N4O3 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1215197-37-7 |
| PubChemID | 46181428 |
| InChIKey | GKMLFBRLRVQVJO-ZDUSSCGKSA-N |
| Smiles | O=C(NC1=CC=C(C(O)=O)C=N1)[C@@H](N2C=NC(C(F)(F)F)=C2)CC3CCCC3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.64 | 100 | |
| ethanol | 39.64 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight396.36.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.52mL | 12.61mL | 25.23mL |
| 5mM | 0.5mL | 2.52mL | 5.05mL |
| 10mM | 0.25mL | 1.26mL | 2.52mL |
| 50mM | 0.05mL | 0.25mL | 0.5mL |
MolarityCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.