Biological Activity
GABAA channel modulator. Binds with high affinity to α6β3γ2 subunit-containing channels.
Technical Data
| M. Wt | 321.33 |
| Formula | C18H15N3O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 164025-44-9 |
| PubChem ID | 10426200 |
| InChI Key | CGOOCGJMECBDCB-UHFFFAOYSA-N |
| Smiles | O=C1C2=CNC3=CC(OC)=CC=C3C2=NN1C(C=C4)=CC=C4OC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.13 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 321.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.11 mL | 15.56 mL | 31.12 mL |
| 5 mM | 0.62 mL | 3.11 mL | 6.22 mL |
| 10 mM | 0.31 mL | 1.56 mL | 3.11 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Varagic et al (2013) Subtype selectivity of α+β- site ligands of GABAA receptors: identification of the first highly specific positive modulators at α6β2/3γ2 receptors. Br.J.Pharmacol. 169 384 PMID: 23472935
Keywords: PZ-II-029, supplier, GABAA, modulators, modulates, selective, high, affinity, alpha6beta3gamma2, a6b3g2, α6β3γ2, GABAA, Receptors, Tocris Bioscience
