BiologicalActivity
Itkinhibitor(pKi=9.2).ExhibitsselectivityforItkoverAuroraBkinaseandBtk(pIC50valuesare6.4and6.5,respectively)andapanelofotherkinases.InhibitsIFNγproductioninPBMCs.
LicensingInformation
SoldforresearchpurposesunderagreementfromGlaxoSmithKline
TechnicalData
| M.Wt | 459.61 |
| Formula | C26H29N5OS |
| Storage | Storeat+4°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 1246030-96-5 |
| Smiles | CCC1=CC=C(N=C(NC3=NC(N[C@H]5CC[C@H](O)CC5)=NC(CC4=CC=CC=C4)=C3)S2)C2=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.HCl | 9.19 | 20 | |
| DMSO | 45.96 | 100 | |
| ethanol | 45.96 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight459.61.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.18mL | 10.88mL | 21.76mL |
| 5mM | 0.44mL | 2.18mL | 4.35mL |
| 10mM | 0.22mL | 1.09mL | 2.18mL |
| 50mM | 0.04mL | 0.22mL | 0.44mL |
MolarityCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.