BiologicalActivity
Potentfarnesyltransferaseinhibitor(IC50=1.9nM).InhibitsfarnesylationofRAS.AlsoinhibitsPgptransport(IC50<3=""μm)=""and=""increases=""potency=""and=""anticancer=""activity=""when=""used=""in=""conjunction=""with=""cytotoxic=""pgp=""substrates.=""inhibits=""neovascularization=""by=""affecting=""cell=""motility.=""orally="">
TechnicalData
| M.Wt | 638.82 |
| Formula | C27H31Br2ClN4O2 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 193275-84-2 |
| PubChemID | 148195 |
| InChIKey | DHMTURDWPRKSOA-RUZDIDTESA-N |
| Smiles | NC(N1CCC(CC1)CC(N2CCC([C@H]3C4=NC=C(C=C4CCC5=CC(Cl)=CC(Br)=C35)Br)CC2)=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 6.39 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight638.82.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.57mL | 7.83mL | 15.65mL |
| 5mM | 0.31mL | 1.57mL | 3.13mL |
| 10mM | 0.16mL | 0.78mL | 1.57mL |
| 50mM | 0.03mL | 0.16mL | 0.31mL |
MolarityCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.