BiologicalActivity
ATP-competitiveinhibitorofDAPK(IC50=200nM)andZIPK(Kd=280nM).AlsoinhibitsPIM3kinase(IC50=200nM)butexhibitsnosignificanteffectonSrcorAblkinases.Reducesphosphorylationofregulatorymyosinlightchainandmyosinlightchainphosphataseinmouseaorticandrabbitilealtissues.
TechnicalData
| M.Wt | 349.8 |
| Formula | C14H12CIN5O2S |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 1030203-81-6 |
| PubChemID | 42938883 |
| InChIKey | BDVPSWBRXLWRCV-UHFFFAOYSA-N |
| Smiles | O=C1NC(SC(C(N)=O)C)=NC2=C1C=NN2C3=CC=CC(Cl)=C3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.49 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight349.8.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.86mL | 14.29mL | 28.59mL |
| 5mM | 0.57mL | 2.86mL | 5.72mL |
| 10mM | 0.29mL | 1.43mL | 2.86mL |
| 50mM | 0.06mL | 0.29mL | 0.57mL |
MolarityCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.