BiologicalActivity
PotentHDAC6inhibitor(IC50=0.015μM).ExhibitssomeselectivelyforHDAC6overHDAC8and1(IC50valuesare0.854and16.4μM,respectively).Induceselevatedlevelsofα-tubulinandprotectsagainstglutathione-inducedoxidativestressinprimaryneuronalcellculture.
TechnicalData
| M.Wt | 371.86 |
| Formula | C20H21N3O2.HCl |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1310693-92-5 |
| PubChemID | 57336514 |
| InChIKey | LJTSJTWIMOGKRJ-UHFFFAOYSA-N |
| Smiles | CN1CCC2=C(C3=CC=CC=C3N2CC4=CC=C(C(NO)=O)C=C4)C1.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.72 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight371.86.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.69mL | 13.45mL | 26.89mL |
| 5mM | 0.54mL | 2.69mL | 5.38mL |
| 10mM | 0.27mL | 1.34mL | 2.69mL |
| 50mM | 0.05mL | 0.27mL | 0.54mL |
MolarityCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.