BiologicalActivity
Potentapelin(APJ)receptoragonist(Ki=0.93nM).ELABELAanalog.ActivatesGαi1pathwayandβ-arrestin-2recruitment.Reducesarterialpressureinrathearts.Activeinvivo.ELA-14negativecontrol(Cat.No.6294)available.
LicensingInformation
SoldunderagreementfromtheAgencyforScience,TechnologyandResearch(A*STAR),ETPL,andaffiliatesincludingtheInstituteofMedicalBiology.
TechnicalData
| M.Wt | 1707.03 |
| Formula | C75H119N25O17S2 |
| Sequence | XRRCMPLHSRVPFP (Modifications:X=Glp) |
| Storage | Storeat-20°C |
| CASNumber | 1886973-05-2 |
| PubChemID | 127043902 |
| InChIKey | LKYSPGTYQNANFL-GYVBEWGNSA-N |
| Smiles | CSCC[C@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCC(=O)N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solubility | Solubleto1mg/mlinwater |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight1707.03.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 0.59mL | 2.93mL | 5.86mL |
| 5mM | 0.12mL | 0.59mL | 1.17mL |
| 10mM | 0.06mL | 0.29mL | 0.59mL |
| 50mM | 0.01mL | 0.06mL | 0.12mL |
MolarityCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.