BiologicalActivity
ClassIHDACinhibitor(IC50valuesare0.18,0.74,44.9and>100μMforHDAC1,3,8and6,respectively).Exhibitsantiproliferativeeffectsandinducesapoptosisinarangeoftumorcelllinesinvitroandinvivo.Increasesestrogenreceptorα-andaromataseexpressioninbreastcancercells.InhibitsPCB-inducedneuronalcelldeathbypreventingHDAC3bindingandhistonedeacetylationwithinthesynapsin-1promoter.
TechnicalData
| M.Wt | 376.41 |
| Formula | C21H20N4O3 |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 209783-80-2 |
| PubChemID | 4261 |
| InChIKey | INVTYAOGFAGBOE-UHFFFAOYSA-N |
| Smiles | O=C(C1=CC=C(C=C1)CNC(OCC2=CN=CC=C2)=O)NC3=CC=CC=C3N |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.64 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight376.41.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.66mL | 13.28mL | 26.57mL |
| 5mM | 0.53mL | 2.66mL | 5.31mL |
| 10mM | 0.27mL | 1.33mL | 2.66mL |
| 50mM | 0.05mL | 0.27mL | 0.53mL |
MolarityCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.