Biological Activity
Biotinylated UNC 1999 (Cat.No. 4904, IC50 = 17 nM). Enriches lysine methyltransferase EZH2 from HEK293T cells.
Licensing Information
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC 1999 probe summary on the SGC website.
Technical Data
M. Wt | 1353.66 |
Formula | C67H104N10O17S |
Storage | Store at -20°C |
Purity | ≥95% (HPLC) |
PubChem ID | 118732748 |
InChI Key | PSDIDGKZEPMSHC-FRQYIUQJSA-N |
Smiles | CC(C)N(N=C1)C2=C1C(C(NCC3=C(CCC)C=C(C)NC3=O)=O)=CC(C(C=C4)=CN=C4N5CCN(C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCCC[C@H]6[C@]([H])([C@]([H])(CS6)N7)NC7=O)=O)=O)CC5)=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 13.54 | 10 |
Preparing Stock Solutions
The following data is based on the product molecular weight 1353.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 0.74 mL | 3.69 mL | 7.39 mL |
5 mM | 0.15 mL | 0.74 mL | 1.48 mL |
10 mM | 0.07 mL | 0.37 mL | 0.74 mL |
50 mM | 0.01 mL | 0.07 mL | 0.15 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Keywords: UNC 2399, supplier, UNC2399, biotinylated, biotin, tag, EZH2, EZH1, histone, methyltransferase, inhibitors, inhibits, UNC1999, pull, down, Lysine, Methyltransferases, Tocris Bioscience