BiologicalActivity
Plasminogenactivatorinhibitor-1(PAI-1)inhibitor(IC50=3.58-60.3μM).Increasesapoptosisinhumancancercelllines.ReducessenescenceandincreasesLifespaninmousemodelsofageing(kl/kl).InhibitsL-NAME(Cat.No.0665)inducedsystolicbloodpressureincreases,telomerelengthreductionandcardiachypertrophyinmice.Renoprotective.Orallybioavailable.
TechnicalData
| M.Wt | 450.8 |
| Formula | C21H16ClN2NaO6 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| PubChemID | 44250349 |
| InChIKey | RDKPAESSEMYFJL-UHFFFAOYSA-M |
| Smiles | O=C(C1=C(C=CC(Cl)=C1)NC(COCC(NC2=CC=CC(C3=COC=C3)=C2)=O)=O)O[Na] |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.08 | 100 | |
| water | 2.25 | 5mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight450.8.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.22mL | 11.09mL | 22.18mL |
| 5mM | 0.44mL | 2.22mL | 4.44mL |
| 10mM | 0.22mL | 1.11mL | 2.22mL |
| 50mM | 0.04mL | 0.22mL | 0.44mL |
MolarityCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.