BiologicalActivity
cdk2inhibitor(IC50=0.5μM).Exhibits>8-foldselectivityforCDK2overCDK1andCDK4(IC50valuesare4.2and215μM,respectively).Inhibitsproliferationratneonatalaorticsmoothmusclecellsandarangeoftumorcellslinesinvitro.Inhibitsrestenosisinaratcarotidarteryinjurymodel.
TechnicalData
| M.Wt | 400.47 |
| Formula | C20H28N6O3 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 199986-75-9 |
| PubChemID | 6918386 |
| InChIKey | NQVIIUBWMBHLOZ-UHFFFAOYSA-N |
| Smiles | COC1=CC=C(C=C1)CNC2=NC(N(CCO)CCO)=NC3=C2N=CN3C(C)C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.05 | 100 | |
| ethanol | 40.05 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight400.47.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.5mL | 12.49mL | 24.97mL |
| 5mM | 0.5mL | 2.5mL | 4.99mL |
| 10mM | 0.25mL | 1.25mL | 2.5mL |
| 50mM | 0.05mL | 0.25mL | 0.5mL |
MolarityCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.