Biological Activity
Adenylyl cyclase 1 (AC1) inhibitor (IC50 = 2.3 μM). Exhibits some selectivity for AC1 over other AC isoforms, with no significant activity against AC8. Inhibits Ca2+/calmodulin-stimulated cAMP accumulation in hippocampal homogenates. Enhances μ opioid receptor (MOR)-mediated inhibition of AC1 in cellular assays and inhibits development and maintenance of MOR-mediated sensitization of AC1. Active in vivo. Analgesic.
Technical Data
| M. Wt | 297.95 |
| Formula | C10H4Cl4O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 133406-29-8 |
| PubChem ID | 867466 |
| InChI Key | NTDHYMSVCBGQJF-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C2OC(C(Cl)(Cl)Cl)=CC(C2=C1)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.8 | 100 | |
| ethanol | 5.96 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 297.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.36 mL | 16.78 mL | 33.56 mL |
| 5 mM | 0.67 mL | 3.36 mL | 6.71 mL |
| 10 mM | 0.34 mL | 1.68 mL | 3.36 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.67 mL |
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References
References are publications that support the products' biological activity.
Brust et al (2017) Identification of a selective small-molecule inhibitor of type 1 adenylyl cyclase activity with analgesic properties. Sci.Signal. 10 eaah5381 PMID: 28223412
Keywords: ST 034307, supplier, ST034307, adenylyl, cyclase, inhibitors, inhibits, AC1, active, in, vivo, analgesic, cAMP, Adenylyl, Cyclase, Tocris Bioscience
