BiologicalActivity
HighaffinityJNKinhibitor(Kivaluesare25-50nM).InhibitsJNKviacompetitivebindingoftheATP-bindingsiteofactive,phosphorylatedJNK.Exhibits>40-foldselectivityforJNKoverp38,ERK,IKK2,proteinkinaseC,LckandZAP70.Hepatoprotective.AlsoinhibitsHCMVreplication.
TechnicalData
| M.Wt | 461.39 |
| Formula | C22H24N6O.2HCl |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| PubChemID | 66576998 |
| InChIKey | LDUPODIOUWRGCQ-UHFFFAOYSA-N |
| Smiles | N1(CCCCC1)CCOC2=CC=CC(C3=NNC4=CC=C(C5=NN=CN5)C=C34)=C2.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.14 | 100 | |
| water | 46.14 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight461.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.17mL | 10.84mL | 21.67mL |
| 5mM | 0.43mL | 2.17mL | 4.33mL |
| 10mM | 0.22mL | 1.08mL | 2.17mL |
| 50mM | 0.04mL | 0.22mL | 0.43mL |
MolarityCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.