BiologicalActivity
PotentSykkinaseinhibitor(IC50=14nM).InhibitsassemblyofNLRP3inflammasomesinducedbyNigericin(Cat.No.4312).Alsoinhibitstheactivationofcaspase-1,IL-1βprocessingandrelease,mitochondrialROSgenerationandpyropticcelldeathinmousemacrophagecells.
TechnicalData
| M.Wt | 353.39 |
| Formula | C18H15N3O3S |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 622387-85-3 |
| PubChemID | 24906266 |
| InChIKey | MLKHXLFEYOOYEY-UHFFFAOYSA-N |
| Smiles | CN1C=C(/C=C2C(NC3=CC=C(C=C23)S(N)(=O)=O)=O)C4=CC=CC=C14 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.34 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight353.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.83mL | 14.15mL | 28.3mL |
| 5mM | 0.57mL | 2.83mL | 5.66mL |
| 10mM | 0.28mL | 1.41mL | 2.83mL |
| 50mM | 0.06mL | 0.28mL | 0.57mL |
MolarityCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.