Biological Activity
Potent and reversible NIMA related kinase 2 (Nek2) inhibitor (IC50 = 56 nM). Induces increased mitotic abnormalities and mitotic delay. Cell permeable and active in vivo.
Technical Data
| M. Wt | 292.3 |
| Formula | C15H12N6O |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 1507367-00-1 |
| PubChem ID | 56944360 |
| InChI Key | CJQGLUJHMXCLQY-UHFFFAOYSA-N |
| Smiles | C#CC1=C2C(NC=N2)=NC(NC3=CC=CC(CC(N)=O)=C3)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.23 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 292.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.42 mL | 17.11 mL | 34.21 mL |
| 5 mM | 0.68 mL | 3.42 mL | 6.84 mL |
| 10 mM | 0.34 mL | 1.71 mL | 3.42 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Lebraud et al (2014) Model system for irreversible inhibition of Nek2: thiol addition to ethynylpurines and related substituted heterocycles. Org.Biomol.Chem. 12 141 PMID: 24213855
Keywords: NCL 00017509, supplier, NCL00017509, NIMA, related, kinase, 2, NEK2, inhibitors, inhibits, mitotic, delay, Nek2, Kinase, Tocris Bioscience
