BiologicalActivity
Nurr1activator.InhibitsNF-κBandcytokineexpressioninmicroglialcellsbystABIlizingnuclearcorepressorproteins,whichreducesbindingofp65toinflammatorygenepromoters.NeuroprotectiveinamouseParkinson'sdiseasemodel.Orallybioavailable.
TechnicalData
| M.Wt | 356.85 |
| Formula | C23H17ClN2 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 178946-89-9 |
| PubChemID | 5302583 |
| InChIKey | LTLRXTDMXOFBDW-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.69 | 100 | |
| ethanol | 35.69 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight356.85.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.8mL | 14.01mL | 28.02mL |
| 5mM | 0.56mL | 2.8mL | 5.6mL |
| 10mM | 0.28mL | 1.4mL | 2.8mL |
| 50mM | 0.06mL | 0.28mL | 0.56mL |
MolarityCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.