BiologicalActivity
Serine/threonineproteinkinase16(STK16)inhibitor(IC50=295nM).ReducescellnumberandincreasesaccumulationofbinucleatedMCF-1cells.Enhancescellapoptosisincombinationwithchemotherapeutics.AlsoinhibitsPI3-KδandPI-3-Kγkinases(IC50valuesare856and867nM,respectively)andmTORkinase(IC50=5.56µM).
LicensingInformation
SoldunderlicensefromWhiteheadInstituteforBiomedicalResearch.
TechnicalData
| M.Wt | 293.3 |
| Formula | C17H12FN3O |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1223001-53-3 |
| PubChemID | 58525066 |
| InChIKey | WQNRDXHKVSKUPI-UHFFFAOYSA-N |
| Smiles | O=C(N1C2=CC(C)=C(F)C=C2)C=CC3=C1C(C=CN4)=C4N=C3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.33 | 100 | |
| ethanol | 2.93 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight293.3.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.41mL | 17.05mL | 34.09mL |
| 5mM | 0.68mL | 3.41mL | 6.82mL |
| 10mM | 0.34mL | 1.7mL | 3.41mL |
| 50mM | 0.07mL | 0.34mL | 0.68mL |
MolarityCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.