BiologicalActivity
PotentNa+/Ca2+exchanger(NCX)inhibitor.InhibitsNCXactivityinratastrocytes,microgliaandculturedneurons,caninecardiacsarcolemmalvesiclesandratcardiomyocytes(IC50valuesare5and8.3,33,90and92nM,respectively).Reducesinfarctvolumesandexhibitsprotectiveeffectsagainstmyocardialischemiainrats.
TechnicalData
| M.Wt | 371.38 |
| Formula | C21H19F2NO3 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 223104-29-8 |
| PubChemID | 644100 |
| InChIKey | YSUBLPUJDOWYDP-UHFFFAOYSA-N |
| Smiles | CCOC1=CC(N)=C(C=C1)OC2=CC=C(C=C2)OCC3=C(C=CC(F)=C3)F |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.14 | 100 | |
| ethanol | 37.14 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight371.38.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.69mL | 13.46mL | 26.93mL |
| 5mM | 0.54mL | 2.69mL | 5.39mL |
| 10mM | 0.27mL | 1.35mL | 2.69mL |
| 50mM | 0.05mL | 0.27mL | 0.54mL |
MolarityCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.