BiologicalActivity
Antiviral.StimulatesexpressionofmiR-185microRNAwhichinhibitsthehepatitisCviruslifecycleviainhibitionofcholesterolbiosynthesisandviruscellmembranefusion.Alsoα-crystallin(cryAB)chaperone(Kd=10.1μM).Blocksα-crystallinaggregationandpartiallyreversescataractformationbybindingandstABIlizingsolubleformsofcryABinvitroandinvivo.
TechnicalData
| M.Wt | 402.65 |
| Formula | C27H46O2 |
| Storage | Storeat-20°C |
| Purity | ≥95%(HPLC) |
| CASNumber | 2140-46-7 |
| PubChemID | 65094 |
| InChIKey | INBGSXNNRGWLJU-ZHHJOTBYSA-N |
| Smiles | O[C@H](C1)CC[C@@]2(C)C1=CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCCC(C)(O)C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.03 | 10mMwithgentlewarming | |
| ethanol | 20.13 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight402.65.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.48mL | 12.42mL | 24.84mL |
| 5mM | 0.5mL | 2.48mL | 4.97mL |
| 10mM | 0.25mL | 1.24mL | 2.48mL |
| 50mM | 0.05mL | 0.25mL | 0.5mL |
MolarityCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.