BiologicalActivity
Potentandrogenreceptor(AR)inhibitor(IC50=69nM).DisruptstheAR-chaperonecomplexbybindingp23andblockingARinteractionwithHSP90causingUPSdegradationofAR.InhibitsHuh7cancercellgrowthviaG0/G1cellcyclearrestandapoptosisinvitroandinvivo.Inhibitsgrowthandmetastasisofcertainprostatecancercelllines.Orallybioavailable.
TechnicalData
| M.Wt | 376.4 |
| Formula | C20H24O7 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 981-15-7 |
| PubChemID | 72965 |
| InChIKey | WBBVXGHSWZIJST-RLQYZCPESA-N |
| Smiles | C=C1[C@]([C@]([C@]2([H])[C@@]3(O)[C@@H]1O)(CO3)[C@@](O4)([H])C[C@@]([C@]2(C)[C@@H]5O)([H])C(C)=CC5=O)([H])CC4=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.64 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight376.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.66mL | 13.28mL | 26.57mL |
| 5mM | 0.53mL | 2.66mL | 5.31mL |
| 10mM | 0.27mL | 1.33mL | 2.66mL |
| 50mM | 0.05mL | 0.27mL | 0.53mL |
MolarityCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.