托克里斯/（±；）-毫升209/5987/10/10毫克
商品编号：
5987
市场价：
¥3700.00
美元价：
2220.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:RORγtinverseagoNIST;suppressesTh17celldifferentiation
ChemicalName:3-(1,3-Benzodioxol-5-yl)-1-(cis-3,5-dimethyl-1-piperidinyl)-3-(2-hydroxy-4,6-dimethoxyphenyl)-1-propanone
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
RORγtinverseagonist(IC50=460nM);suppressesTh17celldifferentiationandIL17Aexpressioninvitro.DoesnotsuppresstranscriptionofRORα.MinimalactivitydisplayedonERα,LXRαandthyroidhormonereceptors(IC50values>4.4μM).
TechnicalData
| M.Wt | 441.52 |
| Formula | C25H31NO6 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1334526-14-5 |
| PubChemID | 53385590 |
| InChIKey | YEKVAIMYYCZDLI-MCPYQZEQSA-N |
| Smiles | COC1=CC(OC)=C(C(O)=C1)C(C2=CC=C3OCOC3=C2)CC(N4C[C@@H](C[C@@H](C4)C)C)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.15 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight441.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.26mL | 11.32mL | 22.65mL |
| 5mM | 0.45mL | 2.26mL | 4.53mL |
| 10mM | 0.23mL | 1.13mL | 2.26mL |
| 50mM | 0.05mL | 0.23mL | 0.45mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
Thereconstitutioncalculatorallowsyoutoquicklycalculatethevolumeofareagenttoreconstituteyourvial.Simplyenterthemassofreagentandthetargetconcentrationandthecalculatorwilldeterminetherest.