BiologicalActivity
L-typecalciumchannelblockerthatdisplaysantihypertensiveproperties.InhibitsCa2+-inducedcontractionsindepolarizedrataorta(IC50=1.9nM)anddisplaysvasoprotectiveeffectsincardiovasculardisease.InhibitsproliferationofhumanvascularsmoothmusclecellsandepidermoidcarcinomaA431cells(IC50=25μM).
CompoundLibraries
AmlodipinebesylateisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 567.05 |
| Formula | C20H25ClN2O5.C6H6O3S |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 111470-99-6 |
| PubChemID | 60496 |
| InChIKey | ZPBWCRDSRKPIDG-UHFFFAOYSA-N |
| Smiles | OS(=O)(=O)C1=CC=CC=C1.CCOC(=O)C1=C(COCCN)NC(C)=C(C1C1=CC=CC=C1Cl)C(=O)OC |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 56.7 | 100 | |
| ethanol | 28.35 | 50 | |
| water | 5.67 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight567.05.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.76mL | 8.82mL | 17.64mL |
| 5mM | 0.35mL | 1.76mL | 3.53mL |
| 10mM | 0.18mL | 0.88mL | 1.76mL |
| 50mM | 0.04mL | 0.18mL | 0.35mL |
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