Biological Activity
Endogenous peptide agonist for amylin, calcitonin, CGRP and adrenomedullin receptors. Inhibits glucagon secretion, delays gastric emptying and acts as a satiety agent. Displays glucose lowering effects in vivo.
Technical Data
| M. Wt | 3903.33 |
| Formula | C165H261N51O55S2 |
| Sequence |
KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY (Modifications: Tyr-37 = C-terminal amide, Disulfide bridge between 2 - 7) |
| Storage | Store at -20°C |
| CAS Number | 122384-88-7 |
| PubChem ID | 16132430 |
| InChI Key | PLOPBXQQPZYQFA-AXPWDRQUSA-N |
| Smiles | [H]N[C@@H](CCCCN)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC1=O)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 5 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 3903.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.26 mL | 1.28 mL | 2.56 mL |
| 5 mM | 0.05 mL | 0.26 mL | 0.51 mL |
| 10 mM | 0.03 mL | 0.13 mL | 0.26 mL |
| 50 mM | 0.01 mL | 0.03 mL | 0.05 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Castillo et al (1995) Amylin/islet polypeptide: biochemistry, physiology, patho-physiology. Diabete Metab. 21 3 PMID: 7781840
Schmitz et al (2004) Amylin agonists: a novel approach in the treatment of diabetes. Diabetes 53 S233 PMID: 15561917
Hoogwerf et al (2008) Pramlintide, the synthetic analogue of amylin: physiology, pathophysiology, and effects on glycemic control, body weight, and selected biomarkers of vascular risk. Vasc.Health Risk Manag. 4 355 PMID: 18561511
Keywords: Amylin, supplier, Endogenous, peptide, agonists, amylin, calcitonin, CGRP, adrenomedullin, receptors, Receptors, Amylin, CT, AMY, Calcitonin, Calcitonin, and, Related, Receptors, Calcitonin, and, Related, Receptors, Tocris Bioscience
