BiologicalActivity
Potentandhighlyselectivearomatase(CYP19)inhibitor(IC50=15nM)thathasnodiscernIBLeeffectonadrenocorticoidhormonesynthesis.Reducesplasmaestrogenlevelsandexhibitsantitumoractivityinvivo.Orallyactive.
LicensingInformation
SoldforresearchpurposesonlyunderagreementfromAstraZeneca
CompoundLibraries
AnastrozoleisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 293.37 |
| Formula | C17H19N5 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 120511-73-1 |
| PubChemID | 2187 |
| InChIKey | YBBLVLTVTVSKRW-UHFFFAOYSA-N |
| Smiles | CC(C)(C#N)C1=CC(CN2C=NC=N2)=CC(C(C)(C)C#N)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.34 | 100 | |
| ethanol | 29.34 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight293.37.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.41mL | 17.04mL | 34.09mL |
| 5mM | 0.68mL | 3.41mL | 6.82mL |
| 10mM | 0.34mL | 1.7mL | 3.41mL |
| 50mM | 0.07mL | 0.34mL | 0.68mL |
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ProductDatasheets
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