Biological Activity
Endogenous peptide fragment. Induces vasorelaxation through release of NO and prostaglandins, perhaps through activation of a non-AT1, non-AT2 receptor, Mas. Counteracts the vasoconstrictive and proliferative effects of angiotensin II and stimulates vasopressin (anti-diuretic hormone) release in vivo.
Technical Data
| M. Wt | 899 |
| Formula | C41H62N12O11 |
| Sequence | DRVYIHP |
| Storage | Desiccate at -20°C |
| CAS Number | 51833-78-4 |
| PubChem ID | 123805 |
| InChI Key | PVHLMTREZMEJCG-GDTLVBQBSA-N |
| Smiles | [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 899. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.11 mL | 5.56 mL | 11.12 mL |
| 5 mM | 0.22 mL | 1.11 mL | 2.22 mL |
| 10 mM | 0.11 mL | 0.56 mL | 1.11 mL |
| 50 mM | 0.02 mL | 0.11 mL | 0.22 mL |
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References
References are publications that support the products' biological activity.
Lemos et al (2002) Angiotensin-(1-7) is involved in the endothelium-dependent modulation of phenylephrine-induced contraction in the aorta of mRen-2 transgenic rats. Br.J.Pharmacol. 135 1743 PMID: 11934815
Santos et al (2000) Angiotensin-(1-7): an update. Regul.Pept. 91 45 PMID: 10967201
Santos et al (2003) Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proc.Natl.Acad.Sci.U.S.A. 100 8258 PMID: 12829792
Keywords: Angiotensin (1-7), supplier, Vasorelaxant, peptide, AT, Receptors, Non-Selective, Angiotensin, agonists, Mas, [Ile5]Angiotensin, I, (1-7), Ang-(1-7), Non-selective, AT, Receptors, Non-selective, AT, Receptors, Tocris Bioscience
