Biological Activity
Endogenous peptide substrate for angiotensin converting enzyme (ACE); precursor to the vasoconstrictor peptide angiotensin II (Cat. No. 1158).
Technical Data
| M. Wt | 1296.5 |
| Formula | C62H89N17O14 |
| Sequence | DRVYIHPFHL |
| Storage | Desiccate at -20°C |
| CAS Number | 484-42-4 |
| PubChem ID | 3081372 |
| InChI Key | ORWYRWWVDCYOMK-HBZPZAIKSA-N |
| Smiles | [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1296.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.77 mL | 3.86 mL | 7.71 mL |
| 5 mM | 0.15 mL | 0.77 mL | 1.54 mL |
| 10 mM | 0.08 mL | 0.39 mL | 0.77 mL |
| 50 mM | 0.02 mL | 0.08 mL | 0.15 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Erdo (1976) Conversion of angiotensin I to angiotensin II. Am.J.Med. 60 749 PMID: 190881
Erdos and Skidgel (1990) Renal metabolism of angiotensin I and II. Kidney Int.Suppl. 30 S24 PMID: 2175370
Manabe et al (1989) Endothelium-dependent contractions induced by angiotensin I and angiotensin II in canine cerebral artery. J.Pharmacol.Exp.Ther. 251 317 PMID: 2795464
Keywords: Angiotensin I (human, mouse, rat), supplier, Endogenous, precursor, angiotensin, II, peptide, ACE, AT, Receptors, Non-Selective, Angiotensin-Converting, Enzyme, Proteinases, Proteases, AngiotensinI, (human, mouse, rat), Non-selective, AT, Receptors, Angiotensin-Converting, Enzyme, Non-selective, AT, Receptors, Tocris Bioscience
