Biological Activity
Endogenous potent vasoconstrictor peptide. Stimulates the synthesis and release of aldosterone.
Technical Data
| M. Wt | 1046.2 |
| Formula | C50H71N13O12 |
| Sequence | DRVYIHPF |
| Storage | Desiccate at -20°C |
| CAS Number | 4474-91-3 |
| PubChem ID | 172198 |
| InChI Key | CZGUSIXMZVURDU-JZXHSEFVSA-N |
| Smiles | [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1046.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.96 mL | 4.78 mL | 9.56 mL |
| 5 mM | 0.19 mL | 0.96 mL | 1.91 mL |
| 10 mM | 0.1 mL | 0.48 mL | 0.96 mL |
| 50 mM | 0.02 mL | 0.1 mL | 0.19 mL |
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References
References are publications that support the products' biological activity.
Clayton et al (1998) Effects of prostaglandins and nitric oxide on the renal effects of angiotensin II in the anaesthetised rat. Br.J.Pharmacol. 124 1467 PMID: 9723960
Mosequeda-Garcia et al (1990) Cardiovascular effects of microinjection of angiotensin II in the brainstem of renal hypertensive rats. J.Pharmacol.Exp.Ther. 255 374 PMID: 2213569
Potts et al (1999) Activation of brain neurons by circulating angiotensin II: direct effects and baroreceptor-mediated secondary effects. Neuroscience 90 581 PMID: 10215161
Keywords: Angiotensin II, supplier, Potent, vasoconstrictor, peptide, AT, Receptors, Non-Selective, Angiotensin, AngiotensinII, Non-selective, AT, Receptors, Non-selective, AT, Receptors, Tocris Bioscience
