![Tocris/[Pyr1]-Apelin-13/2420/1/1 mg](https://www.ebiomall.cn/images/201712/1512521756115821138.jpg)
Biological Activity
Highly potent pyroglutamyl form of apelin-13. Endogenous ligand for apelin APJ receptor (EC50 = 0.37 nM) that displays potent vascular effects in vivo.
Technical Data
| M. Wt | 1533.81 |
| Formula | C69H108N22O16S |
| Sequence |
XRPRLSHKGPMPF (Modifications: X = Glp) |
| Storage | Desiccate at -20°C |
| CAS Number | 217082-60-5 |
| PubChem ID | 25085173 |
| InChI Key | GGMAXEWLXWJGSF-PEWBXTNBSA-N |
| Smiles | [H]N1[C@@H](CCC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1533.81. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.65 mL | 3.26 mL | 6.52 mL |
| 5 mM | 0.13 mL | 0.65 mL | 1.3 mL |
| 10 mM | 0.07 mL | 0.33 mL | 0.65 mL |
| 50 mM | 0.01 mL | 0.07 mL | 0.13 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Katugampola et al (2001) [125I]-(Pyr1)Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man. Br.J.Pharmacol. 132 1255 PMID: 11250876
Kagiyama et al (2005) Central and peripheral cardiovascular actions of apelin in conscious rats. Regul.Pept. 125 55 PMID: 15582714
Tatemoto et al (1998) Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem.Biophys.Res.Comm. 251 471 PMID:
Kleinz et al (2005) Emerging roles of apelin in biology and medicine. Pharmacol.Ther. 107 198 PMID: 15907343
Keywords: [Pyr1]-Apelin-13, supplier, Potent, peptide, agonists, APJ, Receptors, Apelin, adipokines, [pGlu1]-Apelin-13, Apelin, Receptors, Apelin, Receptors, Tocris Bioscience
