Biological Activity
Endogenous apelin receptor agonist. Potently inhibits forskolin-stimulated cAMP accumulation (pIC50 = 9.94).
Technical Data
| M. Wt | 2138.56 |
| Formula | C96H156N34O20S |
| Sequence | KFRRQRPRLSHKGPMPF |
| Storage | Desiccate at -20°C |
| CAS Number | 217082-57-0 |
| PubChem ID | 16130452 |
| InChI Key | SVWSKJCJNAIKNH-MJZUAXFLSA-N |
| Smiles | [H]N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1.20 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 2138.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.47 mL | 2.34 mL | 4.68 mL |
| 5 mM | 0.09 mL | 0.47 mL | 0.94 mL |
| 10 mM | 0.05 mL | 0.23 mL | 0.47 mL |
| 50 mM | 0.01 mL | 0.05 mL | 0.09 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Medhurst et al (2003) Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J.Neurochem. 84 1162 PMID: 12603839
Tatemoto et al (1998) Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem.Biophys.Res.Comms. 251 471 PMID:
De Mota et al (2004) Apelin, a potent diuretic neuropeptide counteracting vasopressin actions through inhibition of vasopressin neuron activity and vasopressin release. Proc.Natl.Acad.Sci. USA 101 10464 PMID:
Keywords: Apelin-17 (human, bovine), supplier, Endogenous, APJ, receptor, agonists, Receptors, Apelin, adipokines, K17F, Prepro-61-77-Apelin, Apelin, Receptors, Apelin, Receptors, Tocris Bioscience
