Biological Activity
NO synthase inhibitor. An NMDA antagonist acting as a competitive inhibitor at the polyamine site.
Technical Data
| M. Wt | 270.31 |
| Formula | C6H16N6.H2SO4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 14923-17-2 |
| PubChem ID | 119020 |
| InChI Key | RWTGFMPOODRXIM-UHFFFAOYSA-N |
| Smiles | O=[SH2]([O])O[O].NC(NCCCCNC(N)=N)=N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 25 mM in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 270.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.7 mL | 18.5 mL | 36.99 mL |
| 5 mM | 0.74 mL | 3.7 mL | 7.4 mL |
| 10 mM | 0.37 mL | 1.85 mL | 3.7 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.74 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Doyle and Shaw (1998) Investigation of the actions and antagonist activity of some polyamine analogues in vivo. Br.J.Pharmacol. 124 386 PMID: 9641557
Reynolds (1990) Arcaine is a competitive antagonist of the polyamine site on the NMDA receptor. Eur.J.Pharmacol. 177 215 PMID: 2155812
Yokoi et al (1994) Structure-activity relationships of arginine analogues on nitric oxide synthase activity in the rat brain. Neuropharmacology 33 1261 PMID: 7532812
Keywords: Arcaine sulfate, supplier, Competitive, NMDA, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience
