Biological Activity
Antioxidant, anti-inflammatory, antiproliferative and antiviral agent. Inhibits LPS-induced iNOS expression via inhibition of IκBα phosphorylation and p65 nuclear translocation (IC50 = 10 nM). Inhibits HIV-1 replication in vitro. Also potently inhibits MKK1 (MEK1) (IC50 = 0.5 nM) and provides neuroprotection by binding to kainate receptors.
Compound Libraries
Arctigenin is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox I. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 372.42 |
| Formula | C21H24O6 |
| Storage | Desiccate at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 7770-78-7 |
| PubChem ID | 64981 |
| InChI Key | NQWVSMVXKMHKTF-JKSUJKDBSA-N |
| Smiles | OC(C=C3)=C(OC)C=C3C[C@@H](C(OC2)=O)[C@H]2CC1=CC(OC)=C(OC)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.24 | 100 | |
| ethanol | 9.31 | 25mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 372.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.69 mL | 13.43 mL | 26.85 mL |
| 5 mM | 0.54 mL | 2.69 mL | 5.37 mL |
| 10 mM | 0.27 mL | 1.34 mL | 2.69 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Cho et al (2002) Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-κBα phosphorylation and of p65 nuclear translocation. Int.Immunopharmacol. 2 105 PMID: 11789661
Jang et al (2002) Arctigenin protects cultured cortical neurons from glutamate-induced neurodegeneration by binding to kainate receptor. J.Neurosci.Res. 68 233 PMID: 11948668
Schroder et al (1990) Differential in vitro anti-HIV activity of natural lignans. Z.Naturforsch.C. 45 1215 PMID: 1965681
Cho et al (2003) Arctigenin, a potent inhibitor of MKK1, inhibits lipopolysaccharide (LPS)-inducible nitric oxide synthase expression through inhibition of I-κBα phosphorylation and of p65 nuclear translocation. Exp.Biol.Abstr. 152.2 PMID:
Keywords: Arctigenin, supplier, inhibitors, IκB, IκBα, IkappaBalpha, phosphorylation, inhibits, MKK1, kainate, receptors, Nuclear, Factor, Kappa, B, Glutamate, Kainate, Receptors, iGluR, Ionotropic, Transcription, Factors, antiviral, NF-kB, NF-kappaB, NF-κB, (-)-Arctigenin, NF-kB/IkB, MEK, Kainate, Receptors, Antivirals, MEK, Tocris Bioscience
