BiologicalActivity
Novelpsychopharmacologicagent.DisplaysantagoNISTactivityat5-HT,dopamine,noradrenalinandhistaminereceptorsubtypes(pKivaluesare8.60,8.40,10.15,9.75,10.46,8.84,9.60,9.94,8.85,8.90,8.84,9.38,8.95,8.93,8.9,9.49,8.91,9.00and8.21for5-HT1A,5-HT1B,5-HT2A,5-HT2B,5-HT2C,5-HT5A,5-HT6,5-HT7,D1,D2L,D2S,D3,D4,α1A,α2A,α2B,α2C,H1andH2receptorsrespectively).Displaysnoappreciableaffinityformuscarinicreceptors.Exhibitspotentactivityinanimalmodelspredictiveofantipsychoticefficacy.
CompoundLibraries
AsenapinemaleateisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 401.84 |
| Formula | C17H16ClNO.C4H4O4 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 85650-56-2 |
| PubChemID | 73416848 |
| InChIKey | QGBIWSABMNWWNB-FGYPTBLJSA-N |
| Smiles | CN2C[C@]1([H])C3=C(C=CC=C3)OC4=C(C=C(Cl)C=C4)[C@]([H])1C2.CN6C[C@@]5([H])C7=C(C=CC=C7)OC8=C(C=C(Cl)C=C8)[C@@]([H])5C6 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.18 | 100 | |
| ethanol | 20.09 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight401.84.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.49mL | 12.44mL | 24.89mL |
| 5mM | 0.5mL | 2.49mL | 4.98mL |
| 10mM | 0.25mL | 1.24mL | 2.49mL |
| 50mM | 0.05mL | 0.25mL | 0.5mL |
MolarityCalculator
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ProductDatasheets
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