BiologicalActivity
PotentHMG-CoAreductaseinhibitor(IC50=8nM).ReducescirculatingLDL-CbyinhibitingcholesterolbiosynthesisandinducingexpressionofLDLreceptors.Inhibitssmoothmusclecellproliferationinvitroandexhibitsantinociceptiveeffectsintheinflammatoryhypernociceptionmodel.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
CompoundLibraries
AtorvastatinhemicalciumsaltisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 577.67 |
| Formula | C33H34FN2O5.½Ca |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 134523-03-8 |
| PubChemID | 60822 |
| InChIKey | FQCKMBLVYCEXJB-MNSAWQCASA-L |
| Smiles | [Ca++].CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C(N1CC[C@@H](O)C[C@@H](O)CC([O-])=O)C1=CC=C(F)C=C1)C1=CC=CC=C1.CC(C)C1=C(C(=O)NC2=CC=CC=C2)C(=C(N1CC[C@@H](O)C[C@@H](O)CC([O-])=O)C1=CC=C(F)C=C1)C1=CC=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 57.77 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight577.67.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.73mL | 8.66mL | 17.31mL |
| 5mM | 0.35mL | 1.73mL | 3.46mL |
| 10mM | 0.17mL | 0.87mL | 1.73mL |
| 50mM | 0.03mL | 0.17mL | 0.35mL |
MolarityCalculator
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ProductDatasheets
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