BiologicalActivity
Macrolideantibiotic.Inhibits50Sribosomalsubunitformationandelongationattranspeptidationstepingram-positiveandgram-negativeorganisms.Orallyactivewithimprovedpharmacokineticsovererythromycininmousemodels.Inhibitsautophagy.
LicensingInformation
SoldforresearchpurposesunderagreementfromPfizerInc.
CompoundLibraries
AzithromycinisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 748.98 |
| Formula | C38H72N2O12 |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 83905-01-5 |
| PubChemID | 447043 |
| InChIKey | MQTOSJVFKKJCRP-BICOPXKESA-N |
| Smiles | [H][C@@]1(O[C@@H]([C@H](C)[C@@H](O[C@@]3([H])[C@H](O)[C@@H](N(C)C)C[C@@H](C)O3)[C@](C)(O)C[C@@H](C)C2)[C@@H](C)C(O[C@H](CC)[C@](O)(C)[C@H](O)[C@@H](C)N2C)=O)O[C@@H](C)[C@H](O)[C@](C)(OC)C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 74.9 | 100 | |
| ethanol | 74.9 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight748.98.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.34mL | 6.68mL | 13.35mL |
| 5mM | 0.27mL | 1.34mL | 2.67mL |
| 10mM | 0.13mL | 0.67mL | 1.34mL |
| 50mM | 0.03mL | 0.13mL | 0.27mL |
MolarityCalculator
ReconstitutionCalculator
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ProductDatasheets
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