Biological Activity
Modulator of unfolded protein response (UPR). Protects cells from ER stress by improving ER protein folding and activating ER chaperone capacity. Also improves ER calcium retention. Improves liver ER function, glucose homeostasis and glucose-stimulated insulin secretion in mouse obesity models. Orally bioavailable.
Technical Data
| M. Wt | 308.83 |
| Formula | C15H17ClN2OS |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 932986-18-0 |
| PubChem ID | 7518316 |
| InChI Key | VYBFWKKCWTXCQX-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(C2=NC(CCNC(CCC)=O)=CS2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.88 | 100 | |
| ethanol | 30.88 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 308.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.24 mL | 16.19 mL | 32.38 mL |
| 5 mM | 0.65 mL | 3.24 mL | 6.48 mL |
| 10 mM | 0.32 mL | 1.62 mL | 3.24 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.65 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Fu et al (2015) Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity. Sci.Transl.Med. 7 292ra98 PMID: 26084805
Keywords: Azoramide, supplier, unfolded, protein, response, UPR, endoplasmic, reticulum, stress, ER, antidiabetic, orally, bioavailable, folding, modulators, PERK, Other, ER, stress/UPR, PERK, Tocris Bioscience
