Biological Activity
Selective α2-adrenoceptor agonist. Exhibits greater than 300-fold selectivity for the α2-adrenoceptor over the α1-adrenoceptor.
Technical Data
| M. Wt | 254.16 |
| Formula | C9H15N3O.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 36067-72-8 |
| PubChem ID | 169743 |
| InChI Key | HBLPYIOKPJVFQW-UHFFFAOYSA-N |
| Smiles | CCN1CCC(OC(N)=N2)=C2CC1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 12.71 | 50 | |
| water | 25.42 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 254.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.93 mL | 19.67 mL | 39.35 mL |
| 5 mM | 0.79 mL | 3.93 mL | 7.87 mL |
| 10 mM | 0.39 mL | 1.97 mL | 3.93 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.79 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Bill et al (1989) The thermogenic actions of α2-adrenoceptor agonists in reserpinized mice are mediated via a central postsynaptic α2-adrenoceptor mechanism. Br.J.Pharmacol. 96 133 PMID: 2564288
Parkinson and Hughes (1995) The mechanism of action of α2-adrenoceptors in human isolated subcutaneous resistance arteries. Br.J.Pharmacol. 115 1463 PMID: 8564206
Kobinger and Pichler (1977) Pharmacological characterization of B-HT 933 (2-amino-6-ethyl-4,5,7,8-tetrahydro-6H-oxazolo-[5,4-d]-azepindihydrochloride) as a hypotensive agent of the "clonidine-type". Naunyn-Schmied.Arch.Pharmacol. 300 39 PMID:
Keywords: B-HT 933 dihydrochloride, supplier, B-HT933, dihydrochloride, azepexole, alpha2, α2, a2, adrenoceptors, agonists, selective, adrenergic, receptors, Azepexole, Adrenergic, Alpha-2, Receptors, Adrenergic, Alpha-2, Receptors, Tocris Bioscience
