Tocris/BAY 41-2272/4430/50/50 mg
商品编号：
4430/50
市场价：
¥16500.00
美元价：
9900.00
产品分类：
其它酶
公司分类：
Other_enzymes
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
Description:Solubleguanylylcyclase(sGC)activator
ChemicalName:5-Cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyrimidinamine
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Activatorofsolubleguanylylcyclase(sGC);actsatanitricoxide(NO)-independentregulatorysiteinthesGCα1subunit.Inhibitsplateletaggregation(IC50=36nM)andphenylephrine-inducedcontractionsofrabbitaorta(IC50=0.30μM).AlsoreducesvascularsmoothmusclegrowththroughcAMP-andcGMP-dependentPKAandPKGpathways.
CompoundLibraries
BAY41-2272isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 360.39 |
| Formula | C20H17FN6 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 256376-24-6 |
| PubChemID | 9798973 |
| InChIKey | ATOAHNRJAXSBOR-UHFFFAOYSA-N |
| Smiles | FC(C=CC=C3)=C3CN2N=C(C4=NC=C(C5CC5)C(N)=N4)C1=CC=CN=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.04 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight360.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.77mL | 13.87mL | 27.75mL |
| 5mM | 0.55mL | 2.77mL | 5.55mL |
| 10mM | 0.28mL | 1.39mL | 2.77mL |
| 50mM | 0.06mL | 0.28mL | 0.55mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet