BiologicalActivity
SelectiveBAZ2bromodomaininhibitor(IC50valuesare130and180nMforBAZ2AandBAZ2Brespectively).Exhibits15-foldselectivityfortheBAZ2bromodomainovertheCERC2bromodomainand>100-foldselectivityoverarangeofotherbromodomains.AcceleratesFRAPrecoveryinaBAZ2AFRAPassay.
LicensingInformation
ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisittheBAZ2-ICRprobesummaryontheSGCwebsite.
ExternalPortalInformation
Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofBAZ2-ICRisreviewedonthechemicalprobeswebsite.
CompoundLibraries
BAZ2-ICRisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 357.41 |
| Formula | C20H19N7 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| PubChemID | 91654625 |
| InChIKey | RRZVGDGTWNQAPW-UHFFFAOYSA-N |
| Smiles | CN(N=C4)C=C4CCN1C=NC(C3=CN(C)N=C3)=C1C2=CC=C(C#N)C=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.74 | 100 | |
| ethanol | 35.74 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight357.41.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.8mL | 13.99mL | 27.98mL |
| 5mM | 0.56mL | 2.8mL | 5.6mL |
| 10mM | 0.28mL | 1.4mL | 2.8mL |
| 50mM | 0.06mL | 0.28mL | 0.56mL |
MolarityCalculator
ReconstitutionCalculator
DilutionCalculator
ProductDatasheets
本网站将在规定时间内给予删除等相关处理。
