Biological Activity
Potent P2X4 receptor antagonist. Blocks P2X4-mediated currents in Chinese hamster ovary cells (IC50 = 0.50 μM).
Compound Libraries
5-BDBD is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 355.19 |
| Formula | C17H11BrN2O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 768404-03-1 |
| PubChem ID | 9841560 |
| InChI Key | NKYMVQPXXTZHSF-UHFFFAOYSA-N |
| Smiles | BrC1=CC(C(C3=C4C2=C(O3)C=CC=C2)=NCC(N4)=O)=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.52 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 355.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.82 mL | 14.08 mL | 28.15 mL |
| 5 mM | 0.56 mL | 2.82 mL | 5.63 mL |
| 10 mM | 0.28 mL | 1.41 mL | 2.82 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Donnelly-Roberts et al (2008) Painful purinergic receptors. J.Pharmacol.Exp.Ther. 324 409 PMID: 18042830
Casati et al (2011) Cell-autonomous regulation of hematopoietic stem cell cycling activity by ATP. Cell Death Differ. 18 396 PMID: 20798687
Keywords: 5-BDBD, supplier, potent, P2X4, antagonists, purinergic, receptors, BDBD, P2X, Receptors, P2X, Receptors, Tocris Bioscience
