Biological Activity
A selective inhibitor of endoplasmic reticulum Ca2+-ATPase.
Technical Data
| M. Wt | 222.33 |
| Formula | C14H22O2 |
| Storage | Store at RT |
| CAS Number | 88-58-4 |
| PubChem ID | 2374 |
| InChI Key | JZODKRWQWUWGCD-UHFFFAOYSA-N |
| Smiles | CC(C)(C)C1=CC(O)=C(C=C1O)C(C)(C)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in DMSO |
Preparing Stock Solutions
The following data is based on the product molecular weight 222.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.5 mL | 22.49 mL | 44.98 mL |
| 5 mM | 0.9 mL | 4.5 mL | 9 mL |
| 10 mM | 0.45 mL | 2.25 mL | 4.5 mL |
| 50 mM | 0.09 mL | 0.45 mL | 0.9 mL |
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References
References are publications that support the products' biological activity.
Dettbarn and Palade (1999) Effects of three sarcoplasmic/endoplasmic Ca++ pump inhibitors on release channels and intracellular stores. J.Pharmacol.Exp.Ther. 285 739 PMID: 9580621
Fusi et al (1999) 2,5-Di-t-butyl-1,4 benzohydroquinone induces endothelium-dependent relaxation of rat thoracic aorta. Eur.J.Pharmacol. 366 181 PMID: 10082199
Hassessian et al (1994) Blockade of the inward rectifier potassium current by the Ca2+-ATPase inhibitor 2',5'-di(tert-butyl)-1,4-benzohydroquinone (BHQ). Br.J.Pharmacol. 112 1118 PMID: 7952872
Jan et al (1999) Mechanism of rise and decay of 2,5-di-tert-butylhydroquinone-induced Ca2+ signals in Madin Darby canine kidney cells. Eur.J.Pharmacol. 365 111 PMID: 9988129
Keywords: BHQ, supplier, inhibitors, inhibits, SERCA, ATPase, Ca2+, modulators, Ca2+-ATPase, Signaling, Signalling, Calcium, P-Type, ATPases, Calcium-ATPase, Ion, Transporters, Pumps, Ca2+-ATPase, Ca2+-ATPase, Tocris Bioscience
