Biological Activity
Selective IKKβ inhibitor (IC50 = 380 nM). Displays no effect on a panel of 100 kinases, except at IGF1 (IC50 = 7.6 μM).
Technical Data
| M. Wt | 432.51 |
| Formula | C17H22F2N4O3S2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 960293-88-3 |
| PubChem ID | 23652660 |
| InChI Key | IYHHRZBKXXKDDY-UHFFFAOYSA-N |
| Smiles | CS(C(CC3)CCN3C1=CC(C(CC)(F)F)=C(C(N)=C(C(N)=O)S2)C2=N1)(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.25 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 432.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.31 mL | 11.56 mL | 23.12 mL |
| 5 mM | 0.46 mL | 2.31 mL | 4.62 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.31 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.46 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Clark et al (2011) Novel cross-talk within the IKK family controls innate immunity. Biochem.J. 434 93 PMID: 21138416
Zhang et al (2014) An unexpected twist to the activation of IKKβ: TAK1 primes IKK beta for activation by autophosphorylation. Biochem.J. 461 531 PMID: 24911653
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