BiologicalActivity
PotentandselectiveBRD9andBRD7inhibitor(Kdvaluesare14and239nM,respectively).ExhibitsselectivityforBRD9/7over48otherbromodomains,324kinasesand55GPCRs.InhibitsproliferationofAMLcelllinesinvitroandreducesAMLtumorxenograftgrowthinvivo.Cellpermeableandorallyactive.
LicensingInformation
ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisittheBI9564probesummaryontheSGCwebsite.
ExternalPortalInformation
Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofBI-9564isreviewedonthechemicalprobeswebsite.
TechnicalData
| M.Wt | 353.41 |
| Formula | C20H23N3O3 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1883429-22-8 |
| PubChemID | 117072549 |
| InChIKey | BJFSUDWKXGMUKA-UHFFFAOYSA-N |
| Smiles | O=C(N(C)C=C1C2=CC(OC)=C(CN(C)C)C=C2OC)C3=C1C=CN=C3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.HCl | 3.53 | 10mMwithgentlewarming | |
| DMSO | 7.07 | 20 | |
| ethanol | 7.07 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight353.41.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.83mL | 14.15mL | 28.3mL |
| 5mM | 0.57mL | 2.83mL | 5.66mL |
| 10mM | 0.28mL | 1.41mL | 2.83mL |
| 50mM | 0.06mL | 0.28mL | 0.57mL |
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