Biological Activity
High affinity NPY Y1 receptor antagonist (IC50 values are 0.38 and 0.72 nM at human and rat receptors respectively) that displays > 2600-fold selectivity over Y2, Y4 and Y5 receptors. Inhibits NPY- and fasting-induced feeding in vivo following central administration. Also antagonizes anxiolytic-like effects of NPY.
Compound Libraries
BIBO 3304 trifluoroacetate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 757.69 |
| Formula | C29H35N7O3.2CF3CO2H |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 191868-14-1 |
| PubChem ID | 5311022 |
| InChI Key | TVMJSGGZULFVCZ-XMMPIXPASA-N |
| Smiles | OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.NC(=N)NCCC[C@@H](NC(=O)C(C1=CC=CC=C1)C1=CC=CC=C1)C(=O)NCC1=CC=C(CNC(N)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 75.77 | 100 | |
| ethanol | 75.77 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 757.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.32 mL | 6.6 mL | 13.2 mL |
| 5 mM | 0.26 mL | 1.32 mL | 2.64 mL |
| 10 mM | 0.13 mL | 0.66 mL | 1.32 mL |
| 50 mM | 0.03 mL | 0.13 mL | 0.26 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Wieland et al (1998) Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents. Br.J.Pharmacol. 125 549 PMID: 9806339
Sajdyk et al (1999) Amygdalar neuropeptide Y Y1 receptors mediate the anxiolytic-like actions of neuropeptide Y in the social interaction test. Eur.J.Pharmacol. 368 143 PMID: 10193650
Lecklin et al (2002) Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea-pig. Br.J.Pharmacol. 135 2029 PMID: 11959807
Keywords: BIBO 3304 trifluoroacetate, supplier, selective, NPY, Y1, receptor, antagonists, Neuropeptide, Y, Receptors, BIBO3304, trifluoroacetate, neuropeptides, NPY, Receptors, NPY, Receptors, Tocris Bioscience
