Biological Activity
Bombesin/GRP receptor agonist that reduces food intake following i.p. administration.
Technical Data
| M. Wt | 1069.27 |
| Formula | C53H76N14O10 |
| Sequence |
FQWAVGHLL (Modifications: Phe-1 = D-Phe, Leu-9 = C-terminal amide) |
| Storage | Store at -20°C |
| CAS Number | 137734-88-4 |
| PubChem ID | 10819959 |
| InChI Key | HLAREJIMNCKKSS-XJZCOZNDSA-N |
| Smiles | [H]N[C@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 2 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1069.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.94 mL | 4.68 mL | 9.35 mL |
| 5 mM | 0.19 mL | 0.94 mL | 1.87 mL |
| 10 mM | 0.09 mL | 0.47 mL | 0.94 mL |
| 50 mM | 0.02 mL | 0.09 mL | 0.19 mL |
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References
References are publications that support the products' biological activity.
Laferrere et al (1992) Effects of bombesin, of a new bombesin agonist (BIM187) and a new antagonist (BIM189) on food intake in rats, in relation to cholecystokinin. Eur.J.Pharmacol. 215 23 PMID: 1516647
Keywords: BIM 187, supplier, Bombesin/GRP, receptor, agonists, GRP-Preferring, Receptors, Gastrin-Releasing, Peptide-Preferring, BB2, BIM187, [D-Phe1,Leu8,9]litorin-NH2, Bombesin, Receptors, Bombesin, Receptors, Tocris Bioscience
